Anna Noble was born in the early 1920s and grew up in Pittsburgh with 11 siblings. She worked as a launderer as a young woman. She applied to several nursing schools, but faced discrimination due to segregation. She attended Mercy Douglass School of Nursing in Philadelphia, which was an all-Black nursing school. In 1950, Noble moved to Detroit to take a nursing position at Haynes Memorial Hospital. She became the director of nursing at DMC Harper University Hospital, where she worked for 23 years. Later in life, she volunteered at the Lula Belle Stewart Center, which offered parenting assistance to single mothers.
Anna Noble was interviewed in partnership with the Museum of African American History of Detroit and Y Arts Detroit in 2010 as part of the Legacies Project.