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TO MOTHERS OF LMGE FAMILIES In this workaday world few women iré so placed that physical exertion is not constantly demanded of them ia their daily life. Mrs. Pinkham makes a special appeal to mothers of large families whose work ís never done, and many of whom suffer kud suffer for lack of intelligent aid. the first approach of weakness, may fill your future years with healthy joy. Mrs. A. C. Buhler, 1123 North Albany avenue, near Humboldt Park, Chicago, 111., says: "I am fifty-one years old and have had twelve cliildren, and my youngest is eight years old. I have been suft'ering for some time with a terrible weakness; that bearing-down feeling was dreadf ui, and I could not walk any distance. I began the use of Lydia E. Pinkham's Vegetable Compound and Sanative Wash and they have cured me. I cannot praise your medicine encugh."