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TO MOTïïERS OF LAEGB FAMILIES In this workaday world few women are so placed that physieal exertion is not constan tly demanded of them in their daily life. Mrs. Pinkham makes a special appeal to mothersof large families whose work is never done, and many of whom suffer and suffer for lack of intelligent aid. lPi 9forA f rom Mrsthe first approach of weakness, may fill your future years with healthy joy. Mrs. A. C. Buhler, 1123 North Albany avenue, near Humboldt Park, Chicago, 111., says: "I am fifty-one years old and have had twelve children, and my youngest is eight years old. I have been suffering for some time with a terrible weakness; that bearing-down feeling was dreadful, and I could not walk any distance. I began the use of Lydia E. Pinkham's Vegetable Compound and Sanative Wash and they have cured me. I cannot praise your medicine enough."